GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs8077889 | 1 | rs59044152 | chr17:41888747 | MPP3 | chr17:41878169-41910538:- | 0.3 | 4.83 | 1.85E-6 | Triglycerides |
| THCA | cis | rs4888671 | 1 | rs59045389 | chr16:77782863 | NUDT7 | chr16:77756411-77776153:+ | 0.35 | 4.82 | 1.9E-6 | Obesity-related traits |
| THCA | cis | rs17122021 | 1 | rs59049611 | chr11:118139403 | AMICA1 | chr11:118064442-118095809:- | 0.08 | 3.79 | 0.000167 | Pain |
| THCA | cis | rs17122021 | 1 | rs59049611 | chr11:118139403 | MPZL2 | chr11:118124135-118135009:- | 0.23 | 7.5 | 3.11E-13 | Pain |
| THCA | cis | rs2157926 | 1 | rs59058733 | chr7:87502048 | DBF4 | chr7:87505544-87538856:+ | -0.29 | -4.36 | 1.57E-5 | Bone mineral density (spine) and age at menarche |
| THCA | cis | rs4915077 | 1 | rs59093593 | chr1:108349457 | VAV3 | chr1:108113782-108507545:- | 0.54 | 7.33 | 1.02E-12 | Hypothyroidism |
| THCA | cis | rs6494537 | 1 | rs590958 | chr15:65735707 | DPP8 | chr15:65737999-65810035:- | -0.09 | -3.9 | 0.000111 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs590958 | chr15:65735707 | SLC24A1 | chr15:65903704-65953256:+ | -0.17 | -4.03 | 6.5E-5 | Mean corpuscular hemoglobin |
| THCA | cis | rs59104589 | 1 | rs59104589 | chr2:242237902 | HDLBP | chr2:242166679-242255254:- | -0.18 | -3.97 | 8.2E-5 | Fibrinogen levels |
| THCA | cis | rs59104589 | 1 | rs59104589 | chr2:242237902 | SEPT2 | chr2:242254723-242293439:+ | -0.18 | -3.65 | 0.000295 | Fibrinogen levels |
| THCA | cis | rs573521 | 1 | rs591058 | chr11:102711338 | MMP1 | chr11:102660641-102668966:- | 0.24 | 4.29 | 2.15E-5 | Cerebrospinal fluid levels of Alzheimer's disease-related proteins |
| THCA | cis | rs2129782 | 1 | rs59107062 | chr8:89405172 | MMP16 | chr8:89049462-89339717:- | 0.31 | 5.04 | 6.5E-7 | Electrodermal activity |
| THCA | cis | rs12435908 | 1 | rs59117465 | chr14:66052472 | LOC645431 | chr14:65877313-65879335:- | -0.61 | -7.58 | 1.81E-13 | Ischemic stroke |
| THCA | cis | rs3774959 | 1 | rs59123962 | chr4:103512451 | NFKB1 | chr4:103422486-103538458:+ | 0.16 | 4.56 | 6.41E-6 | Ulcerative colitis |
| THCA | cis | rs9783347 | 1 | rs59150578 | chr11:18340862 | GTF2H1 | chr11:18343816-18388590:+ | 0.33 | 8.99 | 5.98E-18 | Pancreatic cancer |